Prof. Dr. habil. rer. nat. Marc Brecht

Kontakt

Gebäude 1A
Raum 001
Tel. 07121/ 271 -2065

e-Mail

Forschungsschwerpunkte

Experimentalphysik

Hochauflösende spektroskopische oder mikroskopische Methoden

 

Berufliche Stationen (Auswahl)

  • Prodekan der Fakultät Angewandte Chemie der Hochschule Reutlingen
  • Leiter Physikzentrum der Hochschule Reutlingen
  • Berufung auf die Brückenprofessur für Experimentalphysik zwischen der Hochschule Reutlingen und Universität Tübingen
  • Umhabilitation Physikalische Chemie, Universität Tübingen
  • Habilitation Experimentalphysik, Freie Universität BerlinHabilitationsschrift: Spectroscopy on Pigments-Proteins at the Single-Molecule Level
  • Promotion - Dr.rer.nat., Technische Universität Berlin Note: sehr gut – mit Auszeichnung – Dissertation: Hochfeld- und Puls-EPR-Untersuchungen an den Kofaktoren von [NiFe]-Hydrogenasen: Beiträge zur Klärung des Mechanismuss der biologischen Wasserstoffspaltung

Preise/ Auszeichnungen

2012 Distinguish guest professor (University of Troyes, Frankreich)

2010 Heisenberg-Stipendiat der Deutschen Forschungsgemeinschaft (DFG)

2010 CIC-Stipendiat, Forschungsaufenthalt am IIT Roorkee (Indien)

1996 Physik-Studienpreis der Wilhelm und Else Heraeus-Stiftung

Publikationen

62 Mona Stefanakis, Anita Lorenz, Jörg W. Bartsch, Miriam C. Scholz, Alexandra Wagner, Marc Brecht, Axel Pagenstecher, Jens Schittenhelm, Barbara Boldrini, Sabrina Hakelberg, Susan Noell, Christopher Nimsky, Marcos Tatagiba, Rainer Ritz, Karsten Rebner, Edwin Ostertag: Acquisition of spectroscopic multimodal datasets for the characterization of formalin fixed and nativeprimary brain tumor tissues,(submitted)

61 Quan Liu, Frank Wackenhut, Otto Hauler, Miriam Scholz, Sven zur Oven-Krockhaus, Rainer Ritz, Pierre-Michel Adam, Marc Brecht and Alfred J. Meixner: Hypericin: Single Molecule Spectroscopy of an Active Natural Drug,J Phys Chem A(2020) DOI: 10.1021/acs.jpca.9b11532

60 Achim Junginger, Frank Wackenhut, Alexander Stuhl, Felix Blendinger, Marc Brecht and Alfred J. Meix-ner: Tunable strong coupling of two adjacent opticalλ/2 Fabry-Perot microresonators,Optics Express28 485-493 (2020)

59 Tobias Drieschner, Edwin Ostertag, Barbara Boldrini, Anita Lorenz, Marc Brecht and Karsten Rebner: Direct optical detection of cell density and viability of mammalian cells by means of UV/VIS spectroscopy,Analytical and Bioanalytical Chemistry(2020), DOI: 10.1007/s00216-019-02322-y

58 Katharina Urdl, Stephanie Weiss, Alexandra Karpa, Matea Peric, Edith Zikulnig-Rusch, Marc Brecht, Andreas Kandelbauer, Uwe Müller, Wolfgang Kern: Furan-functionalised melamine-formaldehyde particles performing Diels-Alder reactions,European Polymer Journal108 225-234 (2018)

57Marc Brecht: Chris D. Geddes (Ed.): Surface plasmon enhanced, coupled and controlled fluorescence, Anal Bioanal Chem 410 2455 (2018)

56 Michael Metzger, Alexander Konrad, Felix Blendinger, Andreas Modler, Alfred J. Meixner, Volker Bucherand Marc Brecht: Low-Cost GRIN-Lens-Based Nephelometric Turbidity Sensing in the Range of 0.1–1000 NTU,Sensors18(4) 1115 (2018), DOI: 10.3390/s18041115

55 Alfred J. Meixner, Frank Wackenhut, Alexander Konrad, Michael Metzger and Marc Brecht: λ/2 Fabry Pérot micro-resonators in single molecule spectroscopy, EPJ Web of Conferences190 02007 (2018), DOI: 10.1051/epjconf/201819002007

54 Sepideh Skandary, Frank Müh, Imran Ashraf, Mohamed Ibrahim, Michael Metzger, Athina Zouni, AlfredJ. Meixner and Marc Brecht: Role of missing carotenoid in reducing the fluorescence of single monomeric photosystem II core com-plexes,Phys. Chem. Chem. Phys.19 13189-13194 (2017), DOI: 10.1039/C6CP07748J

53 Imran Ashraf, Alexander Konrad, Heiko Lokstein, Sepideh Skandary, Michael Metzger, Joseph M. Djou-da, Thomas Maurer, Pierre M. Adam, Alfred J. Meixner and Marc Brecht:Temperature dependence of metal-enhanced fluorescence of photosystem I from Thermosynechococ-cus elongatus,Nanoscale9 4196-4204 (2017), DOI: 10.1039/C6NR08762K

52 Johannes Maisch, Farhad Jafarli, Thomas Chassé, Felix Blendinger, Alexander Konrad, Michael Metzger, Alfred J. Meixner, Marc Brecht, L. Dähne and Hermann A. Mayer: One-pot synthesis of micron partly hollow anisotropic dumbbell shaped silica core-shell particles,Chemical Communications 52 14392-14395 (2016), DOI: 10.1039/C6CC07372G

51 Alexander Konrad, Michael Metzger, Andreas Kern, Marc Brecht and Alfred J. Meixner: Revealing the radiative and non-radiative relaxation rates of the fluorescence dye Atto488 in a λ/2 Fabry-Perot-resonator by spectrally and time resolved measurements, Nanoscale8 14541-14547 (2016), DOI: 10.1039/C6NR02380K

50 Michael Metzger, Alexander Konrad, Sepideh Skandary, Imran Ashraf, Alfred J. Meixner, Marc Brecht: Resolution enhancement for low-temperature scanning microscopy by cryo-immersion,Opt. Express24 12 ((2016), DOI: 10.1364/OE.24.013023

49 Sepideh Skandary, Alexander Konrad, Martin Hussels, Alfred J. Meixner,Marc Brecht:Orientations between Red Antenna States of Photosystem I Monomers from Thermosynechococcuselongatus Revealed by Single-Molecule Spectroscopy,J. Phys. Chem. B119 13888-13896 (2015)

48 Sepideh Skandary, Alexander Konrad, Martin Hussels, Alfred J. Meixner, Marc Brecht: Polarization-dependent single-molecule spectroscopy on photosystem I,Proc. SPIE9554 (2015)

47 Skandary Sepideh, Hussels Martin, Konrad Alexander, Renger Thomas, Mueh Frank, Bommer Martin, Zouni Athina, Meixner Alfred and Marc Brecht:Variation of Exciton-Vibrational Coupling in Photosystem II Core Complexes from Thermosynechococcuselongatus as Revealed by Single-Molecule SpectroscopyJ. Phys Chem B119 13888-13896 (2015)

46 Imran Ashraf, Sepideh Skandary, Mohammad Y. Khaywah, Michael Metzger, Alfred J. Meixner, Pierre M.Adam, Marc Brecht: Effects of Irregular Bimetallic Nanostructures on the Optical Properties of Photosystem I from Thermo-synechococcus elongatus,Photonics2(3) 838-854 (2015)

45 Alexander Konrad, Michael Metzger, Andreas M. Kern, Marc Brecht, Alfred J. Meixner:Controlling the dynamics of F ̈orster resonance energy transfer inside a tunable sub-wavelength Fabry-P ́erot-resonator,Nanoscale7 10204-10209 (2015)

44 Alexander Konrad, Andreas M. Kern, Marc Brecht, Alfred J. Meixner:Strong and Coherent Coupling of a Plasmonic Nanoparticle to a Subwavelength Fabry–Pérot Resonator,Nano Letters15(7) 4423-8 (2015)

43 Alexander Konrad, Anna-Lisa Trost, Sepideh Skandary, Martin Hussels, Alfred J. Meixner, Navassard V.Karapetyan and Marc Brecht: Manipulating the excitation transfer in Photosystem I by a Fabry-Perot metal resonator with optical sub-wavelength dimensionsPCCP16 6175-6181 (2014)

42 Eberhard Schlodder, Friedhelm Lendzian, Jenny Meyer, Marianne Cetin, Marc Brecht, Thomas Renger, and Navasard V. Karapetyan: Long-wavelength limit of photochemical energy conversion in photosytem IJ. Am. Chem. Soc.136 3904–3918 (2014)

41Marc Brecht, Sepideh Skandary, Julia Hellmich, Carina Gl ̈ockner, Alexander Konrad, Martin Hussels,Alfred J. Meixner, Athina Zouni, Eberhard Schlodder:Spectroscopic Properties of Photosystem II Core Complexes from Thermosynechococcus elongatusRevealed by Single-Molecule ExperimentsBBA - Bioenergetics1837 773-781 (2014)

40 Jana B. Nieder, Martin Hussels, Robert Bittl, Marc Brecht: Effect of TMAO and Betaine on the Energy Landscape of Photosystem IBBA – Bioenergetics837 849-856 (2014)

39 Michael Metzger, Alexander Konrad, Tobias Menold, Hyeyun Go,Andreas Horrer, Sabrina Rau, Andreas Modler, Günther Gauglitz, Monika Fleischer, Dieter Kern, Dai Zhang, Alfred J. Meixner, Marc Brecht: Kompakter Sensor f ̈ur raumaufgel ̈oste Echtzeitmessungen des Brechungsindexes mit Hilfe eines opti-schen Resonators und Gradienten-Index-OptikPhotonik1 (2014)

38 N.V. Karapetyan, Yu.V. Bolychevyseva, N.P. Yurina, I.V. Terekhova, V.V. Shubin, and Marc Brecht: Long-wavelength chlorophylls in photosystem I of cyanobacteria: origin, localization, and function,Biochemistry (Moscow)79 (2014)

37 Andreas M. Kern, Dai Zhang, Marc Brecht, Alexey Chizhik, Antonio Virgilio Failla, Frank Wackenhut, Alfred J. Meixner: Enhanced single-molecule spectroscopy in highly confined optical fields: Fromλ4/2-Fabry-Perot resonators to plasmonic nano-antennas, Chemical Society Reviews 43 1263-1286 (2014)

36 Frank Schleifenbaum, Christian Blum, Marc Brecht, Alfred J. Meixner:Single Molecule spectroscopy,In: Handbook of spectroscopy (2014)

35 Alexander Konrad, Frank Wackenhut, Andreas Kern, Martin Hussels, Alfred J. Meixner, Marc Brecht: Temperature dependance of luminescence and dephasing of Au nanorods,The Journal of Physical Chemistry C117 21476-21482 (2013)

34/P1 Martin Hussels, Marc Brecht: Patent for a fast sample exchange mechanism for low temperatures, (2012) patent

33 Martin Hussels, Alexander Konrad, Marc Brecht: Confocal sample-scanning microscope for single-molecule spectroscopy and microscopy with quick sam-ple exchange at 4.2 K, Rev. Sci. Inst.83 123706 (2012)

32Marc Brecht: Nanoparticles affect the function of photosystem I, BBA – Bioenergetics1817 S29 (2012)

31 Marc Brecht, Martin Hussels, Jana B. Nieder, Hui Fang, Celine Elsässer:Plasmonic Interactions of Photosystem I with Fischer Patterns Made of Gold and Silver, Chemical Physics 406 15-20 (2012)

30 Martin Hussels, Jana B. Nieder, Celine Elsässer, Marc Brecht: Interactions of Photosystem I with Plasmonic Nanostructures, Acta Physica Polonica A122 269-274 (2012)

29Marc Brecht, Martin Hussels, Eberhard Schlodder, Navassard V. Karapetyan: Red Antenna States of Photosystem I fromArthrospira platensis, BBA – Bioenergetics1817 445-452 (2012)

28 Eberhard Schlodder, Martin Hussels, Marianne Cetin, Navassard V. Karapetyan, Marc Brecht: Fluorescence of the various red antenna states in photosystem I complexes from cyanobacteria is affec-ted differently by the redox state of P700,BBA – Bioenergetics1807 1423–31 (2011)

27 Martin Hussels, Marc Brecht: Evidence for Direct Binding of Glycerol to the Surface of Photosystem I,Febs Letters585 2445–2449 (2011)

26 Martin Hussels, Marc Brecht: Effect of Glycerol and PVA on Protein Conformation,Biochemistry50 3628–3637 (2011)

25 Jana Nieder, Robert, Bittl, Marc Brecht: Fluoreszenzstudien zum Einfluss plasmonischer Wechselwirkungen auf die Funktion eines Proteins,Angewandte Chemie52 10415-10418 (2010)

24 Jana Nieder, Robert, Bittl, Marc Brecht: Plasmonic Interactions Affect Protein Function,Angewandte Chemie Int. Ed.49 10217-10220 (2010)

23 Miguel Saggu, Christian Teutloff, Marcus Ludwig, Marc Brecht, Maria-Eirini Pandelia, Oliver Lenz, Bärbel Friedrich, Wolfgang Lubitz, Peter Hildebrandt, Friedhelm Lendzian, and Robert Bittl: Comparative investigation of the oxidized ready state of the membrane-bound [NiFe] hydrogenases fromR. eutropha H16 and D. vulgaris Miyazaki F with pulsed EPR spectroscopy, ChemPhysChem 11(6) 1215-1224 (2010)

22 Marc Brecht Review: Spectroscopic characterization of PSI on the single-molecule level,Molecular Physics107 1955-1974 (2009)

21Marc Brecht, Volker Radics, Jana Nieder, Robert Bittl:Protein Dynamics-Induced Variation of Excitation Energy Transfer Pathways,Proc. Natl. Acad. Sci. USA106(29) 11857-11861 (2009)

20 Jana Nieder, Marc Brecht, Robert Bittl:Dynamic intra-complex heterogeneity of Phytochrome,J. Am. Chem. Soc.131(1) 69–71 (2009)

19Marc Brecht, Volker Radics, Jana Nieder, Robert Bittl:Anti-Correlation of the Emission from Different Red Pools in Photosystem I,Proceedings of SPIE7185 718506-1-10 (2009)

18Marc Brecht, Hauke Studier, Volker Radics, Robert Bittl:Spectral Diffusion Induced by Hydrogen Dynamics in Proteins,J. Am. Chem. Soc.130 (51) 17487–17493 (2008)

17 Marc Brecht, Volker Radics, Jana Nieder, Hauke Studier, Robert Bittl:Red Antenna States of Photosystem I fromSynechocystisPCC 6803,Biochemistry47(20) 5536-5543 (2008)

16 Marc Brecht, Jana B. Nieder, Hauke Studier, Eberhard Schlodder, Robert Bittl:Red Antenna States of Photosystem I fromSynechococcussp. PCC 7002,Photosynthesis Research95(2-3) 155-165 (2008)

15Marc Brecht, Hauke Studier, Jana B Nieder, Volker Radics, Robert Bittl:Single Molecule Spectroscopy on Photosystem I,In: P Hinterdorfer, G Sch ̈utz, P Pohl (ed.),Proceedings of the IX. Linz Winter Workshop 2007, in Schrif-tenreihe Biophysik, pages 64-68. Trauner (2007)

14Marc Brecht, Hauke Studier, Alexandra F. Elli, Fedor Jelezko, Robert Bittl:Assignment of red antenna states in photosystem I fromThermosynechococcus elongatusby singlemolecule spectroscopy,Biochemistry46(3) 799-806 (2007)

13 Alexandra F. Elli, Fedor Jelezko, Carsten Tietz, Hauke Studier, Marc Brecht, Robert Bittl, Jörg Wrachtrup: Red pool chlorophylls of Photosystem I of the cyanobacterium Thermosynechococcus elongatus: a single molecule study, Biochemistry45(5) 1454-1458 (2006)

12 Maurice van Gastel, Matthias Stein, Marc Brecht, Olga Schröder, Friedhelm Lendzian, Robert Bittl, Hideaki Ogata, Yoshiki Higuchi, Wolfgang Lubitz:A Single Crystal ENDOR and Density Functional Theory Study of the Oxidized States of the [NiFe]Hydrogenase fromD. vulgaris Miyazaki F, J. Biol. Inorg. Chem.11(1) 41-51 (2006)

11 Stefanie Foerster, Maurice van Gastel, Marc Brecht, Wolfgang Lubitz:An orientation-selected ENDOR and HYSCORE study of the Ni-C active state of Desulfovibrio vulgaris Miyazaki F hydrogenase, J. Biol. Inorg. Chem.10(1) 51-62 (2005)

10 Celine Elsässer, Marc Brecht, Robert Bittl: Treatment of spin-coupled metal-centers in pulsed electron-electron double resonance experiments,Biochem. Soc. Trans.33(1) 15-19 (2005)

9 Stefanie Foerster, Matthias Stein, Marc Brecht, Hideaki Ogata, Yoshiki Higuchi, Wolfgang Lubitz: Single crystal EPR studies of the reduced active site of [NiFe] hydrogenase fromDesulfiovibrio vulgaris Miyazaki F, J. Am. Chem. Soc.125(1) 83-93 (2003)

8 Wolfgang Lubitz, Marc Brecht, Stefanie Foerster, Maurice van Gastel, Matthias Stein: EPR and ENDOR studies of [NiFe] hydrogenase: Contributions to understanding the mechanism ofbiological hydrogen conversion,In: (ed.), Paramagnetic Resonance of Metallobiomolecules, in ACS Symposium Series128-149 (2003)

7 Marc Brecht, Maurice van Gastel, Torsten Buhrke, Bärbel Friedrich, Wolfgang Lubitz: Direct detection of a hydrogen ligand in the [NiFe] center of the regulatory H-2-sensing hydrogenase from Ralstonia eutrophain its reduced state by HYSCORE and ENDOR spectroscopy, J. Am. Chem. Soc.125(43) 13075-13083 (2003)

6 Wolfgang Lubitz, Marc Brecht, Stefanie Foerster, Matthias Stein, Yoshiki Higuchi, Torsten Buhrke, Bärbel Friedrich: EPR and theoretical investigations of [NiFe] hydrogenase: Insight into the mechanism of biological hy-drogen conversion, EPR in the 21stCENTURY: Basics and Applications to Material, Life and Earth Science 437-445 (2002)

5 Torsten Buhrke, Marc Brecht, Wolfgang Lubitz, Bärbel Friedrich:The H-2 sensor of Ralstonia eutropha: biochemical and spectroscopic analysis of mutant proteins modi-fied at a conserved glutamine residue close to the [NiFe] active site,J. Biol. Inorg. Chem.7(7-8) 897-908 (2002)4 Celine Elsässer, Marc Brecht, Robert Bittl: Pulsed Electron-Electron Double Resonance on Multi-Nuclear Metal Clusters: Assignment of Spin Pro-jection Factors Based on the Dipolar Interaction, J. Am. Chem. Soc.124(42) 12606-12611 (2002)

3 Wolfgang Lubitz, Matthias Stein, Marc Brecht, Olga Trofanchuk, Stefanie Foerster, Yoshiki Higuchi, Ericvan Lenthe, Friedhelm Lendzian:Single crystal EPR and DFT studies of the paramagnetic states of [NiFe] hydrogenase from Desulfovibrio vulgaris, Biophysical Journal 78(1) 281A-281A (2000)

2Marc Brecht, Beate Klosgen, Christoph Reichle, Klaus D. Kramer:Distribution function in the description of relaxation phenomena,Molecular Physics96(2) 149-160 (1999)

1Marc Brecht, Matthias Stein, Olga Trofanchuck, Freidhelm Lenditian, Robert Bittl, Yoshiki Higuchi, Wolf-gang LubitzCatalytic Center of the [NiFe] Hydrogenase: A Pulse ENDOR and ESEEM Study,In: (ed.), Magnetic Resonance and Related Phenomena 818-819 (1998)